ELECTROPHYSIOLOGICAL ANALYSIS OF SYNAPTIC TRANSMISSION

Electrophysiological description of mechanisms determining synaptic transmission and its modulation.

Signal integration in neurons is a complex process that depends on e.g. the kinetics of synaptic currents, distribution of synaptic connections as well as passive and excitatory membrane properties. The time course of synaptic currents is largely determined by the kinetics of the postsynaptic receptors and the time course of synaptic neurotransmitter concentration. The analysis of current respo...

Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae.

We report functional neuronal and synaptic transmission properties in Drosophila CNS neurons. Whole cell current- and voltage-clamp recordings were made from dorsally positioned neurons in the larval ventral nerve cord. Comparison of neuronal Green Fluorescent Protein markers and intracellular dye labeling revealed that recorded cells consisted primarily of identified motor neurons. Neurons had...

An Electrophysiological Analysis of Synaptic Transmission at the Drosophila Larval Neuromuscular Junction

The Analysis of Nonlinear Synaptic Transmission

From the Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, and the Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77550. Dr. Krausz's present address is the Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77550, and Dr. Friesen's is the Department of Biology',...

The analysis of nonlinear synaptic transmission

In order to characterize synaptic transmission at a unitary facilitating synapse in the lobster cardiac ganglion, a new nonlinear systems analysis technique for discrete-input systems was developed and applied. From the output of the postsynaptic cell in response to randomly occurring presynaptic nerve impulses, a set of kernels, analogous to Wiener kernels, was computed. The kernels up to thir...